Software defined networking for radio telescopes: a case study on the applicability of SDN for MeerKAT

Scientific instruments like radio telescopes depend on high-performance networks for internal data exchange. The high bandwidth data exchange between the components of a radio telescope makes use of multicast networking. Complex multicast networks are hard to maintain and grow, and specific installations require modified network switches. This study evaluates Software Defined Networking (SDN) for use in the MeerKAT radio telescope to alleviate the management complexity and allow for a vendor-neutral implementation. The purpose of this dissertation is to verify that an SDN multicast network can produce suitable paths for data flow through the network and to see if such an implementation is easier to maintain and grow. There is little literature regarding SDN for radio telescope networks; however, there is considerable work where different aspects of SDN are discussed and demonstrated for video streaming. SDN with multicast for video streaming, although simpler, forms the background research. Considerable work was put into understanding and documenting the different aspects of a radio telescope affecting the data network. The telescope network controller generates the OpenFlow rules required by the SDN controller and is a new concept introduced in this work. The telescope network controller is fitted with two placement algorithms to demonstrate its flexibility. Both algorithms are suitable for the expected workload, but they produce very different traffic patterns. The two algorithms are not compared to one another, they were created to demonstrate the ease of adding domain specific knowledge to an SDN. The telescope network controller makes it easy to introduce and use new flow placement algorithms, thus making traffic engineering feasible for the radio telescope. Complex multicast networks are easier to maintain and grow with SDN. SDN allows customised packet forwarding rules typically unattainable with standard routing and other standard network protocols and implementations. A radio telescope with a software-defined data network is resilient, easier to maintain, vendor-neutral, and possesses advanced traffic engineering mechanisms

Vinflunine: a new active drug for second-line treatment of advanced breast cancer. Results of a phase II and pharmacokinetic study in patients progressing after first-line anthracycline/taxane-based chemotherapy

To evaluate the single agent activity, pharmacokinetics and tolerability of the novel tubulin targeted agent vinflunine (VFL) (320 mg m−2 q 21 days) as second-line chemotherapy in patients with metastatic breast carcinoma (MBC). All patients had disease progression after anthracycline/taxane (A/T) therapy. They could have received a nonanthracycline adjuvant treatment and subsequently received a first-line A/T combination for advanced/metastatic disease; or relapsed >6 months after completion of adjuvant A/T therapy and were subsequently treated with the alternative agent; or relapsed within 6 months from an adjuvant A/T combination. Objective response was documented in 18 of 60 patients enrolled (RR: 30% (95% confidence interval (CI): 18.9–43.2%)). Among the responders, seven patients had relapsed during a period of <3 months from taxane-based regimen yielding a RR of 33.3%. The median duration of response was 4.8 months (95% CI: 4.2–7.2), median progression-free survival was 3.7 months (95% CI: 2.8–4.2) and median overall survival was 14.3 months (95% CI: 9.2–19.6). The most frequent adverse event was neutropenia (grade 3 in 28.3% and grade 4 in 36.7% of patients). No febrile neutropenia was observed. Fatigue (grade 3 in 16.7% of patients) and constipation (grade 3 in 11.7% of patients) were also common; these were non-cumulative and manageable permitting achievement of a good relative dose intensity of 93.5%. Vinflunine is an active agent with acceptable tolerance in the management of MBC patients previously treated with (A/T)-based regimens. These encouraging phase II results warrant further investigation of this novel agent in combination with other active agents in this setting or in earlier stages of disease

Carbohydrate intake and obesity

The prevalence of obesity has increased rapidly worldwide and the importance of considering the role of diet in the prevention and treatment of obesity is widely acknowledged. This paper reviews data on the effects of dietary carbohydrates on body fatness. Does the composition of the diet as related to carbohydrates affect the likelihood of passive over-consumption and long-term weight change? In addition, methodological limitations of both observational and experimental studies of dietary composition and body weight are discussed. Carbohydrates are among the macronutrients that provide energy and can thus contribute to excess energy intake and subsequent weight gain. There is no clear evidence that altering the proportion of total carbohydrate in the diet is an important determinant of energy intake. However, there is evidence that sugar-sweetened beverages do not induce satiety to the same extent as solid forms of carbohydrate, and that increases in sugar-sweetened soft drink consumption are associated with weight gain. Findings from studies on the effect of the dietary glycemic index on body weight have not been consistent. Dietary fiber is associated with a lesser degree of weight gain in observational studies. Although it is difficult to establish with certainty that fiber rather than other dietary attributes are responsible, whole-grain cereals, vegetables, legumes and fruits seem to be the most appropriate sources of dietary carbohydrate. © 2007 Nature Publishing Group